Ledin T, Odkvist L M, Möller C
Department of ENT, University Hospital, Linköping, Sweden.
Acta Otolaryngol Suppl. 1995;520 Pt 2:310-2. doi: 10.3109/00016489509125258.
The effects of classical sedating antihistamines on cognitive and perceptual functions are well known. Loratadine is a new antihistamine without sedative effects. In this study, loratadine 10 and 40 mg daily, clemastine 2 mg twice daily and placebo were evaluated in 8 healthy subjects in terms of effects on equilibrium as measured with dynamic posturography. Dynamic posturography comprises a sensory organization part in which the support surface and visual surround are either stable or referenced to the patient's sway, with eyes open or closed. In a movement coordination part, the platform makes active movements. Analysis of variance showed no effects on equilibrium attributable to loratadine. Comparing substances pairwise, however, a significant difference between loratadine and clemastine was displayed in 2 out of 6 sensory test conditions. In conclusion, loratadine can be considered safe regarding balance functions.
经典镇静抗组胺药对认知和感知功能的影响是众所周知的。氯雷他定是一种无镇静作用的新型抗组胺药。在本研究中，对8名健康受试者评估了每日10毫克和40毫克的氯雷他定、每日两次2毫克的氯马斯汀及安慰剂对动态姿势描记法测量的平衡的影响。动态姿势描记法包括一个感觉组织部分，其中支撑面和视觉环境在睁眼或闭眼时可以是稳定的，也可以参考患者的摇摆情况。在运动协调部分，平台会进行主动运动。方差分析表明氯雷他定对平衡无影响。然而，两两比较各物质时，在6种感觉测试条件中的2种条件下，氯雷他定和氯马斯汀之间显示出显著差异。总之，就平衡功能而言，氯雷他定可被认为是安全的。
