Nikolova K
Clinic of Dermatology and Venereology, Higher Medical Institute, Sofia, Bulgaria.
Methods Find Exp Clin Pharmacol. 1995 Oct;17(8):545-9.
The effect of nifedipine in the treatment of hypertensive venous leg ulcers was studied on 30 outpatients in a double-blind placebo-controlled trail over a period of 2 months. The dose of nifedipine or the matching placebo was 10 mg 3 times daily. Most of the subjective symptoms such as pain, paraesthesia and cramps at night considerably improved during the treatment with nifedipine and were slightly affected in the placebo group. The ulcer surface area decreased after 2 months treatment with nifedipine by 26.9% (p < 0.05), and after treatment with placebo by 8.6% (p > 0.05). An improvement of the photopletysmographic record of the lower legs in the nifedipine group was observed, demonstrated by an increase of the index recovery time (by 36.1%, p < 0.05), while there were no significant changes in the placebo group. The results show favorable effect of nifedipine in the treatment of hypertensive venous leg ulcers which might be due to a great extent to improvement of the subcutaneous circulation of the lower legs. Nifedipine may be an important adjunct to the conservative management of the complications caused by chronic venous insufficiency and hypertension.
在一项为期2个月的双盲安慰剂对照试验中，对30名门诊患者研究了硝苯地平治疗高血压性下肢静脉溃疡的效果。硝苯地平或匹配安慰剂的剂量为每日3次，每次10毫克。在使用硝苯地平治疗期间，大多数主观症状如疼痛、感觉异常和夜间痉挛有显著改善，而在安慰剂组中受影响较小。用硝苯地平治疗2个月后溃疡表面积减少了26.9%（p<0.05），用安慰剂治疗后减少了8.6%（p>0.05）。观察到硝苯地平组小腿光电容积描记图有所改善，表现为指数恢复时间增加（增加36.1%，p<0.05），而安慰剂组无显著变化。结果表明硝苯地平治疗高血压性下肢静脉溃疡有良好效果，这在很大程度上可能是由于小腿皮下循环得到改善。硝苯地平可能是慢性静脉功能不全和高血压所致并发症保守治疗的重要辅助药物。
