Dueymes M, Piette J C, Le Tonquèze M, Bendaoud B, Roué R, Garré M, Youinou P
Laboratory of Immunology, Brest University Medical School, France.
Lupus. 1995 Dec;4(6):477-81. doi: 10.1177/096120339500400610.
The binding capacity to cardiolipin and the functional affinity of affinity-purified anticardiolipin (aCL) IgG of patients with autoimmune disease have been compared with those of individuals with malaria and acquired immunodeficiency syndrome (AIDS). The binding of autoimmune IgG aCL was enhanced gradually by the incorporation of increasing amounts of beta 2-glycoprotein I (beta 2GPI) into the assay, in contrast to that of patients with infectious diseases. In addition, there were significant reductions of functional affinity in autoimmune disease, but not in malaria or in AIDS. These results indicate that beta 2GPI requirement for binding to the target antigen varies inversely with functional affinity in autoimmune disease when beta 2GPI was present, and suggest that IgG aCL are more heterogeneous in this type of disorder than in patients with infectious disease.
已将自身免疫性疾病患者亲和纯化的抗心磷脂（aCL）IgG与疟疾患者及获得性免疫缺陷综合征（AIDS）患者的该抗体对心磷脂的结合能力和功能亲和力进行了比较。与传染病患者不同，自身免疫性IgG aCL的结合会随着检测中β2糖蛋白I（β2GPI）加入量的增加而逐渐增强。此外，自身免疫性疾病中功能亲和力显著降低，而疟疾或AIDS患者则不然。这些结果表明，在存在β2GPI的情况下，自身免疫性疾病中与靶抗原结合对β2GPI的需求与功能亲和力呈负相关，提示IgG aCL在这类疾病中比在传染病患者中更具异质性。
