多种5-取代和2,5-二取代的1,3-二氧杂环己烷，一类新型镇痛药。
Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents.
作者信息
Booher R N, Smits S E, Turner W W, Pohland A
出版信息
J Med Chem. 1977 Jul;20(7):885-90. doi: 10.1021/jm00217a003.
PMID:874963
Abstract
A series of 5-substituted and 2,5-disubstituted 1,3-dioxanes was prepared and evaluated for analgesic activity in mice and rats. Some of the compounds possessed significant analgesic effects; their structure-activity relationships and chemistry are discussed. These compounds represent a unique series of analgesic agents.
摘要
制备了一系列5-取代和2,5-二取代的1,3-二氧杂环己烷，并在小鼠和大鼠中评估其镇痛活性。其中一些化合物具有显著的镇痛作用；讨论了它们的构效关系和化学性质。这些化合物代表了一类独特的镇痛剂。
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