Maida E, Summer K
J Neurol. 1979 Mar 22;220(2):143-8. doi: 10.1007/BF00313955.
The adrenocortical function in 52 multiple sclerosis patients was studied and compared to that of ten healthy control subjects. The basic secretion rate of cortisol of the MS patients was within the range of normal. Reactivity of the adrenal cortex to stimulation by synthetic ACTH was markedly reduced independent of the duration of the disease with the exception of four patients who were in an early stage of the disease. No difference could be demonstrated between patients undergoing a bout and patients in a stage of remission. The pathogenetic and prognostic significance of the results of the present study are discussed.
对52例多发性硬化症患者的肾上腺皮质功能进行了研究，并与10名健康对照者的肾上腺皮质功能进行了比较。多发性硬化症患者皮质醇的基础分泌率在正常范围内。除4例处于疾病早期的患者外，无论病程长短，肾上腺皮质对合成促肾上腺皮质激素刺激的反应性均显著降低。正在发作的患者与缓解期的患者之间未显示出差异。本文讨论了本研究结果的发病机制和预后意义。
