Bashir R M, Lipman T O
Georgetown University Medical Center, Washington, DC 20007, USA.
Gastroenterol Clin North Am. 1995 Dec;24(4):1003-25.
The enzymology and clinical manifestations of total parenteral nutrition (TPN)-induced liver abnormalities have been investigated extensively. The cause, pathogenesis, and treatment of TPN-related hepatic and biliary dysfunction in adults still are not well understood, however. The findings of experimental studies in animals has not necessarily correlated with the human data, and there have been few prospective, randomized controlled trials examining the mechanism, cause, or treatment of TPN-induced hepatobiliary toxicity in adults. This article examines the animal models of pathogenesis and treatment of TPN-induced intrahepatic and extrahepatic abnormalities, and provides a discussion of abnormalities seen in humans.
全胃肠外营养（TPN）诱导的肝脏异常的酶学及临床表现已得到广泛研究。然而，成人TPN相关肝和胆汁功能障碍的病因、发病机制及治疗仍未完全明确。动物实验研究结果不一定与人类数据相关，而且很少有前瞻性、随机对照试验来研究成人TPN诱导的肝胆毒性的机制、病因或治疗。本文探讨了TPN诱导的肝内和肝外异常的发病机制及治疗的动物模型，并对人类中出现的异常情况进行了讨论。
