人类8号染色体长臂远端40个基因座的辐射杂种图谱。
A radiation hybrid map of 40 loci for the distal long arm of human chromosome 8.
作者信息
Lewis T B, Nelson L, Ward K, Leach R J
机构信息
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio 78284, USA.
出版信息
Genome Res. 1995 Nov;5(4):334-41. doi: 10.1101/gr.5.4.334.
We generated a panel of 97 radiation hybrids from the cell line GM10156B, which contains only human chromosome 8 in a Chinese hamster ovary cell line background. Statistical analysis of the cosegregation of markers in the 97 radiation hybrids was used to construct a physical map delineating the order and intermarker distance of 40 8q24 loci. Twenty-one loci were ordered with maximum likelihood ratios greater than 1000:1. A high level of consistency was seen between our RH map and the published genetic map, suggesting that our panel will be a valuable resource for the rapid mapping of markers derived from human chromosome 8.
我们从细胞系GM10156B中产生了一组97个辐射杂种，该细胞系在中国仓鼠卵巢细胞系背景中仅包含人类8号染色体。通过对97个辐射杂种中标记共分离情况的统计分析，构建了一个物理图谱，描绘了40个8q24位点的顺序和标记间距离。21个位点的排序具有大于1000:1的最大似然比。我们的辐射杂种图谱与已发表的遗传图谱之间呈现出高度一致性，这表明我们的这组辐射杂种将成为快速定位源自人类8号染色体标记的宝贵资源。
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