来自人类5号染色体长臂远端部分的44个基因座的连续高分辨率辐射杂种图谱。

A contiguous high-resolution radiation hybrid map of 44 loci from the distal portion of the long arm of human chromosome 5.

作者信息

Warrington J A, Wasmuth J J

机构信息

Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717, USA.

出版信息

Genome Res. 1996 Jul;6(7):628-32. doi: 10.1101/gr.6.7.628.

DOI:10.1101/gr.6.7.628

PMID:8796350

Abstract

A contiguous high-resolution map of 44 loci from a 35-Mb portion of the distal region of the long arm of human chromosome 5, q21-q35, was produced using radiation hybrid (RH) mapping in conjunction with a natural deletion mapping panel. The map includes 30 genes, four sequence-tagged site (STS) loci, and 10 DNA markers. Newly mapped markers fill two gap regions that were present in previous maps, between markers FER-IL4 and IL3-IL9. Identifying the position of genes on the physical map aids in positional cloning efforts and contributes to our understanding of the overall organization of the human genome.

摘要

利用辐射杂种（RH）作图法并结合一个自然缺失作图组，构建了人类5号染色体长臂远端区域（q21 - q35）35兆碱基部分的44个位点的连续高分辨率图谱。该图谱包括30个基因、4个序列标签位点（STS）和10个DNA标记。新定位的标记填补了先前图谱中存在的两个空白区域，即FER - IL4和IL3 - IL9标记之间的区域。确定基因在物理图谱上的位置有助于定位克隆研究，并有助于我们了解人类基因组的整体组织。