Rosier P F, de la Rosette J J, Wijkstra H, Van Kerrebroeck P E, Debruyne F M
Department of Urology, University Hospital Nijmegen, Netherlands.
Neurourol Urodyn. 1995;14(6):625-33. doi: 10.1002/nau.1930140604.
Analysis of 185 consecutive patients with BPH revealed concomitant detrusor instability in 20% of the patients. Of all patients 30.9% were not obstructed, 51.8% were moderately obstructed and 17.3% were severely obstructed. Patients with detrusor instability during filling cystometry revealed no differences in average age, prostate volume or symptoms. Mean filling cystometry parameters revealed earlier sense of urge correlating with higher pressures at lower volumes in patients with detrusor instability. Pressure-flow analysis showed no differences between the patients with and without detrusor instability in bladder outflow obstruction parameters. Further analysis, however, revealed that the prevalence of patients with detrusor instability reaches a "steady state" at a moderate level of obstruction. On clinical epidemiological grounds, the conclusion is made that detrusor instability is developing in the early phase of obstruction. Probably detrusor instability and bladder outflow obstruction are concomitant, due to the aging process in many of these patients.
对185例连续性良性前列腺增生（BPH）患者的分析显示，20%的患者伴有逼尿肌不稳定。在所有患者中，30.9%无梗阻，51.8%为中度梗阻，17.3%为重度梗阻。在膀胱测压充盈期出现逼尿肌不稳定的患者，其平均年龄、前列腺体积或症状无差异。平均膀胱测压参数显示，在逼尿肌不稳定的患者中，较低容量时较早出现尿急感且与较高压力相关。压力-流率分析显示，有和没有逼尿肌不稳定的患者在膀胱流出道梗阻参数方面无差异。然而，进一步分析显示，在中度梗阻水平时，逼尿肌不稳定患者的患病率达到“稳态”。基于临床流行病学依据，得出结论：逼尿肌不稳定在梗阻早期发展。在许多此类患者中，可能由于衰老过程，逼尿肌不稳定与膀胱流出道梗阻并存。
