Broso P R, Buffetti G
Divisione di Ostetricia e Ginecologia, USSL n. 9, Ospedale Civile, Ivrea, Torino.
Minerva Ginecol. 1996 Jan-Feb;48(1-2):45-7.
The question of whether vulvar Paget's disease is an intraepidermal disease with potential to invade the underlying dermis or a tumor of adnexal origin with spread to the overlying epidermis remains to be resolved. The most common complaint is pruritus. The lesion is described as red, inflamed or erythematous. The delay in diagnosis is considerable in most cases. The disease can be diagnosed only by biopsy. The lesion frequently extends beyond the clinically apparent borders. The disease without underlying invasive carcinoma appears to remain as an intraepithelial malignancy for a long time. The high incidence of other malignancies (breast, colon, cervix, ovary) warrants careful examination in patients with Paget's disease of the vulva. Close follow-up for a longer period of time will be necessary before excluding recurrence. A major goal of conservative surgery is to preserve sexual function, normal anatomy and body image.
外阴佩吉特病究竟是一种有侵袭下方真皮层潜力的表皮内疾病，还是一种起源于附属器并蔓延至上方表皮的肿瘤，这一问题仍有待解决。最常见的症状是瘙痒。病变表现为红色、发炎或红斑状。在大多数情况下，诊断延迟时间较长。该病只能通过活检来诊断。病变常常超出临床可见的边界。没有潜在浸润性癌的该病似乎会长期保持为上皮内恶性肿瘤。其他恶性肿瘤（乳腺癌、结肠癌、宫颈癌、卵巢癌）的高发病率使得对外阴佩吉特病患者进行仔细检查很有必要。在排除复发之前，需要进行更长时间的密切随访。保守手术的一个主要目标是保留性功能、正常解剖结构和身体形象。
