通过聚合酶链反应（PCR）技术将人类过氧化物酶体棕榈酰辅酶A氧化酶基因定位于染色体17q23 - qter。
Assignment of the human peroxisomal palmitoyl-CoA oxidase gene to chromosome 17q23-qter by PCR technique.
作者信息
Moghrabi N N, Dawson D B, Bennett M J
机构信息
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Children's Medical Center of Dallas, USA.
出版信息
J Inherit Metab Dis. 1995;18(6):705-9. doi: 10.1007/BF02436760.
PMID:8750608
Abstract
Human peroxisomal palmitoyl-CoA oxidase plays a pivotal role in the beta-oxidation of fatty acids. Its importance is reflected by the severity of the disease associated with its deficiency in man. The gene was previously mapped to chromosome 17q25 with a FISH technique and is now confirmed using a PCR technique.
摘要
人类过氧化物酶体棕榈酰辅酶A氧化酶在脂肪酸的β氧化过程中起关键作用。其重要性通过人类中与其缺乏相关疾病的严重程度得以体现。该基因先前通过荧光原位杂交技术定位于17号染色体长臂25区，现在通过聚合酶链反应技术得以证实。
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