Kuschel B, Estey E
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Leuk Lymphoma. 1995 Dec;20(1-2):153-5. doi: 10.3109/10428199509054767.
We describe two patients who showed a very similar, but atypical course of acute myelogenous leukemia. They demonstrated skin nodules, spinal fluid and CNS involvement whereas bone marrow and blood remained clear. Nonetheless both had cytogenetic findings of trisomy 8 in the marrow and were resistant to a combination of cytarabine, idarubicin, fludarabine, and granulocyte-colony stimulating factor.
我们描述了两名急性髓系白血病患者，他们呈现出非常相似但不典型的病程。他们出现了皮肤结节、脑脊液及中枢神经系统受累，而骨髓和血液检查结果却均正常。尽管如此，两人骨髓的细胞遗传学检查结果均显示8号染色体三体，并且对阿糖胞苷、伊达比星、氟达拉滨及粒细胞集落刺激因子联合治疗耐药。
