Ziółkowska B, Höllt V
Physiologisches Institut, Universität Müchen, Germany.
Brain Res Mol Brain Res. 1995 Dec 28;34(2):351-4. doi: 10.1016/0169-328x(95)00209-b.
The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration. Mice were treated with haloperidol (1 mg/kg, i.p., once daily), MK-801 (1 mg/kg, i.p., twice daily), or with both those drugs for 9 days. Pretreatment with MK-801 prevented the haloperidol-produced induction of the striatal c-fos mRNA. In animals injected with haloperidol for 9 days, levels of the striatal PENK mRNA were increased by 100%. Coadministration of MK-801 did not reduce that increase. These results suggest that Fos is not necessary for activation of the PENK gene expression, produced by chronic haloperidol application, in the striatum.
本研究的目的是确定氟哌啶醇诱导小鼠纹状体中c-fos基因是否是反复给予氟哌啶醇后纹状体前脑啡肽原（PENK）基因表达增加的原因。小鼠分别接受氟哌啶醇（1mg/kg，腹腔注射，每日一次）、MK-801（1mg/kg，腹腔注射，每日两次）或这两种药物联合处理9天。MK-801预处理可阻止氟哌啶醇诱导的纹状体c-fos mRNA表达。在注射氟哌啶醇9天的动物中，纹状体PENK mRNA水平增加了100%。联合给予MK-801并没有降低这种增加。这些结果表明，在纹状体中，Fos对于慢性应用氟哌啶醇所产生的PENK基因表达激活并非必需。
