Johansson C, Stark A, Sandberg M, Ek B, Rask L, Meijer J
Department of Cell Research, Swedish University of Agricultural Sciences, Uppsala.
Arch Toxicol. 1995;70(1):61-3. doi: 10.1007/s002040050250.
The soluble epoxide hydrolase mRNA level in liver was increased eight-fold upon administration of the hypolipidemic drug and peroxisome proliferator clofibrate for 7 days to mice. The soluble epoxide hydrolase mRNA was back at control levels within 1-2 days after clofibrate withdrawal. The highest expression was in liver, intestine and kidney. Lower levels were found in heart and muscle and very low levels were found in testes, lung, brain and spleen. The mRNA levels were increased in liver, kidney and heart by clofibrate.
给小鼠连续7天施用降血脂药物和过氧化物酶体增殖剂氯贝丁酯后，肝脏中可溶性环氧化物水解酶的mRNA水平增加了8倍。停用氯贝丁酯后1-2天内，可溶性环氧化物水解酶的mRNA恢复到对照水平。最高表达出现在肝脏、肠道和肾脏中。在心脏和肌肉中发现的水平较低，而在睾丸、肺、脑和脾脏中发现的水平非常低。氯贝丁酯使肝脏、肾脏和心脏中的mRNA水平升高。
