Mueller A J, Medele R, Nasemann J
Augenklinik der Universität München.
Ophthalmologe. 1995 Oct;92(5):708-13.
Although Terson's syndrome has been diagnosed more frequently since the early 1960s because of improved intensive-care facilities, these reports are single case reports or retrospective studies. Therefore, we examined prospectively 20 patients (11 male, 9 female), aged between 23 and 77 years, with subarachnoid hemorrhages or rapid increase in intracranial pressure (ICP) of other origin (tumor-associated, post-traumatic) to evaluate ocular changes. In all patients the increase in ICP was confirmed by computed tomography. Additionally, in 16 patients permanent monitoring of ICP was performed. Twelve patients presented with subarachnoid hemorrhage, 6 had a post-traumatic increase in ICP, and 2 more presented with a tumor-associated intracranial hemorrhage. A total of 8 patients (40%) presented with intraocular changes; 6 presented with uni- or bilateral intraretinal hemorrhage, 1 patient had a bilateral papilledema and 1 more patient had bilateral vitreal hemorrhage. When ocular hemorrhage occurred, the mortality was 2.5 times as high as in patients without ocular hemorrhage. For this prognostic feature of the ophthalmological status all patients with rapid increase in ICP should be monitored early for intraocular hemorrhage. The possibility of intraocular hemorrhage is elevated in high-degree subarachnoid hemorrhage, whereas a rapid increase in ICP also found when the pressure has other causes (tumor-associated, posttraumatic).
自20世纪60年代初以来,由于重症监护设施的改善,Terson综合征的诊断更为频繁,但这些报告均为单病例报告或回顾性研究。因此,我们前瞻性地检查了20例患者(男11例,女9例),年龄在23至77岁之间,患有蛛网膜下腔出血或其他原因(肿瘤相关性、创伤后)导致的颅内压(ICP)快速升高,以评估眼部变化。所有患者的颅内压升高均通过计算机断层扫描得以证实。此外,16例患者进行了颅内压的持续监测。12例患者出现蛛网膜下腔出血,6例创伤后颅内压升高,另外2例出现肿瘤相关性颅内出血。共有8例患者(40%)出现眼部变化;6例出现单眼或双眼视网膜内出血,1例患者出现双侧视乳头水肿,1例患者出现双侧玻璃体出血。发生眼部出血时,死亡率是无眼部出血患者的2.5倍。鉴于眼部状况的这一预后特征,所有颅内压快速升高的患者均应尽早监测是否发生眼内出血。在重度蛛网膜下腔出血时,眼内出血的可能性增加,而当颅内压升高由其他原因(肿瘤相关性、创伤后)引起时也会出现颅内压的快速升高。