Shier M R, Wilson R F, James R E, Riddle J, Mammen E F, Pedersen H E
J Trauma. 1977 Aug;17(8):621-9.
Significant coagulation and blood gas changes may occur with uncomplicated extremity fractures. To more accurately define the effect of therapy on these changes, a prospective study of 58 patients with uncomplicated fractures was undertaken. An initial group of 10 selected patients was studied to determine the changes with "standard therapy." The remaining 48 patients were then randomized into five groups: control, increased fluid intake, increased glucose intake, aspirin, and massive steroids. The patients were studied on 5 consecutive days. Treatment of patients in the latter four groups with aspirin or steroids resulted in significant normalization of blood gases, coagulation proteins, and platelet numbers when compared to controls. These measurements in patients treated with fluid loading or increased glucose intake were not significantly different from controls.
单纯性四肢骨折可能会出现显著的凝血和血气变化。为了更准确地确定治疗对这些变化的影响，对58例单纯性骨折患者进行了一项前瞻性研究。首先选取10例患者组成初始组，研究“标准治疗”下的变化。其余48例患者随后被随机分为五组：对照组、增加液体摄入量组、增加葡萄糖摄入量组、阿司匹林组和大剂量类固醇组。对患者连续进行5天的研究。与对照组相比，后四组患者使用阿司匹林或类固醇治疗后，血气、凝血蛋白和血小板数量显著恢复正常。接受液体负荷或增加葡萄糖摄入量治疗的患者的这些测量值与对照组无显著差异。
