Paintaud G, Helleday L, Maboundou C W, Alván G
Department of Clinical Pharmacology, Besançon University Hospital, France.
Eur J Clin Pharmacol. 1995;49(1-2):139-43. doi: 10.1007/BF00192372.
A computer program applying the principle of maximum entropy to the analysis of drug absorption rate has been developed. Plasma concentrations of amoxicillin obtained after oral and intravenous dosing have been analysed, together with simulated data corresponding to a complex input. Amoxicillin absorption rates devised by the program were similar to those obtained by a standard deconvolution method, although they were displayed as an almost continuous profile. However, improbable fluctuations were obtained with some data sets and the fraction absorbed was underestimated by 13%. With the simulated data, the maximum entropy program did not provide a better solution than the standard deconvolution procedure, and it was sensitive to the addition of random error and to the number of samples. The maximum entropy principle, as implemented in our computer program, may not have a better performance than standard deconvolution procedures, especially in human experiments where the number of blood samples is usually limited.
已开发出一种将最大熵原理应用于药物吸收速率分析的计算机程序。对口服和静脉给药后获得的阿莫西林血浆浓度以及对应复杂输入的模拟数据进行了分析。该程序设计的阿莫西林吸收速率与通过标准去卷积方法获得的吸收速率相似，尽管它们呈现出几乎连续的曲线。然而，某些数据集出现了不太可能的波动，并且吸收分数被低估了13%。对于模拟数据，最大熵程序并未提供比标准去卷积程序更好的解决方案，并且它对随机误差的添加和样本数量敏感。在我们的计算机程序中实现的最大熵原理可能并不比标准去卷积程序表现更好，特别是在血样数量通常有限的人体实验中。
