Ikeda Y, Kajiyama K, Adachi E, Yamagata M, Shimada M, Yanaga K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hepatogastroenterology. 1995 Sep-Oct;42(5):469-72.
BACKGROUND/AIMS: In 231 patients with hepatocellular carcinoma who underwent liver resection from 1986 to 1992 to determine the significance of alpha-fetoprotein (AFP) levels.
There were 13 patients (5.6 per cent) with early recurrence within six months after hepatectomy.
Preoperative serum alpha-fetoprotein (AFP) levels were significantly higher in patients with early recurrence (p < 0.01). Postoperative histological examination revealed that there were significant correlations between patients with early recurrence and intrahepatic metastasis (p < 0.01), and portal vein infiltration (p < 0.01). There were significant correlations between patients with early recurrence and preoperative diagnosis of intrahepatic metastasis (p < 0.01), however, preoperative diagnosis of portal vein infiltration could not be detected enough. Eight (73%) of 11 patients with over 1000 ng/ml of AFP and preoperative diagnosis of intrahepatic metastasis had early recurrence (p < 0.01).
We found that patients of hepatocellular carcinoma with over 1000 ng/ml of AFP and preoperative diagnosis of intrahepatic metastasis are the most important factors in the preoperative clinical data linked to early recurrence type of HCC after hepatectomy.
背景/目的：对1986年至1992年间接受肝切除的231例肝细胞癌患者进行研究，以确定甲胎蛋白（AFP）水平的意义。
有13例患者（5.6%）在肝切除术后6个月内出现早期复发。
早期复发患者的术前血清甲胎蛋白（AFP）水平显著更高（p<0.01）。术后组织学检查显示，早期复发患者与肝内转移（p<0.01）和门静脉浸润（p<0.01）之间存在显著相关性。早期复发患者与术前肝内转移诊断之间存在显著相关性（p<0.01），然而，术前门静脉浸润诊断的检出率不足。11例AFP超过1000 ng/ml且术前诊断为肝内转移的患者中有8例（73%）出现早期复发（p<0.01）。
我们发现，AFP超过1000 ng/ml且术前诊断为肝内转移的肝细胞癌患者是肝切除术后与肝癌早期复发类型相关的术前临床数据中最重要的因素。
