Cullis J O, Win N, Dudley J M, Kaye T
Lewisham Hospital, London, UK.
Vox Sang. 1995;69(4):355-7. doi: 10.1111/j.1423-0410.1995.tb00373.x.
Delayed haemolytic transfusion reactions (DHTRs) are seen more frequently in patients with sickle cell disease (SCD) than in other groups of patients, and are characterised by a positive direct antiglobulin test and the appearance of previously undetected red blood cell (RBC) alloantibodies in the patient's serum. Recently a syndrome of post-transfusion hyperhaemolysis has been described in children with SCD, characterised by destruction of both autologous and transfused RBCs with negative serological findings: continuation of RBC transfusion exacerbated haemolysis further. We describe a case of life-threatening post-transfusion hyperhaemolysis in an adult patient with SCD in whom severe anaemia necessitated further RBC transfusion, which was successfully performed in conjunction with intravenous immunoglobulin. This approach may be useful in the management of post-transfusion hyperhaemolysis in SCD as well as in the management of severe DHTRs.
延迟性溶血性输血反应（DHTRs）在镰状细胞病（SCD）患者中比在其他患者群体中更常见，其特征为直接抗球蛋白试验阳性以及患者血清中出现先前未检测到的红细胞（RBC）同种抗体。最近，在患有SCD的儿童中描述了一种输血后高溶血综合征，其特征是自体和输入的RBC均被破坏，血清学检查结果为阴性：继续输注RBC会进一步加重溶血。我们描述了一例成年SCD患者发生危及生命的输血后高溶血的病例，该患者因严重贫血需要进一步输注RBC，通过联合静脉注射免疫球蛋白成功完成了输血。这种方法可能对SCD输血后高溶血的管理以及严重DHTRs的管理有用。
