Rosenkranz H S, Liu M, Cunningham A, Klopman G
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
SAR QSAR Environ Res. 1996;5(2):79-98. doi: 10.1080/10629369608031709.
The expert structure-activity relational system CASE/MULTICASE was used to obtain an assessment of the possible carcinogenicity of selligueain A, a plant-derived sweetener. Based upon a series of authoritative data bases it was predicted that this chemical had some marginal potential for being a 'non-genotoxic' rodent carcinogen. The relevance of this potential to possible human health risks is problematic. Still, given the fact that successful sweetener may be widely consumed, should this chemical be developed further, experimental determinations of its potential carcinogenicity appear in order.
运用专家结构-活性关系系统CASE/MULTICASE对一种植物源甜味剂——光叶蕨素A的潜在致癌性进行评估。基于一系列权威数据库预测，这种化学物质有一定的可能性成为“非遗传毒性”啮齿动物致癌物。这种可能性与人类健康风险的相关性存在问题。然而，鉴于成功的甜味剂可能会被广泛食用，如果进一步开发这种化学物质，对其潜在致癌性进行实验测定似乎是必要的。
