Murphy K J, O'Connell A W, Regan C M
Department of Pharmacology, University College, Dublin, Ireland.
J Neurochem. 1996 Sep;67(3):1268-74. doi: 10.1046/j.1471-4159.1996.67031268.x.
Polysialylated neurons, located at the inner border of the dentate granule cell layer, have been demonstrated to exhibit time-dependent change in their frequency at 10-12 h following training in the Morris water maze, a spatial learning paradigm. Such a change was not observed in animals required to locate a visible platform or in those rendered amnesic with scopolamine. This frequency response was capable of rapid reactivation following further training stimuli in a manner that was independent of circadian influence. These learning-associated modulations in neural cell adhesion molecule (NCAM) polysialylation state did not increase in magnitude despite improved performance, suggesting their activation is required for processing information rather than contributing to previously stored, task-associated memory. An increase in NCAM polysialylation appears to be a universal learning response to both spatial and nonspatial paradigms as similar time-dependent changes occurred following training in a one-trial, step-through, passive avoidance response subsequent to water maze training.
多唾液酸化神经元位于齿状颗粒细胞层的内边界，在空间学习范式——莫里斯水迷宫训练后的10 - 12小时，已被证明其频率呈现时间依赖性变化。在需要定位可见平台的动物或用东莨菪碱致失忆的动物中未观察到这种变化。这种频率反应在进一步训练刺激后能够快速重新激活，且方式不受昼夜节律影响。尽管表现有所改善，但神经细胞黏附分子（NCAM）多唾液酸化状态的这些与学习相关的调节幅度并未增加，这表明其激活是处理信息所必需的，而非有助于先前存储的与任务相关的记忆。NCAM多唾液酸化的增加似乎是对空间和非空间范式的一种普遍学习反应，因为在水迷宫训练后的一次性、穿梭式、被动回避反应训练后也发生了类似的时间依赖性变化。
