Nakanishi Y
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Dec;33 Suppl:24-8.
The number of hematopoietic stem cells circulating in peripheral blood increases remarkably during the recovery of marrow function after myelosuppressive chemotherapy. In peripheral blood stem cell transplantation, these stem cells are collected and cryopreserved, and then used to restore marrow function after myelodisruptive (high-dose) anticancer therapy, Marrow recovery is faster with this procedure than with autologous bone marrow transplantation. Recently, this procedure has been used after high-dose chemotherapy for chemosensitive solid tumors such as breast cancer. We used high-dose chemotherapy with etoposide and carboplatin, followed by peripheral blood stem cell transplantation, to treat 5 patients with intrathoracic malignant tumors, including small cell lung cancer Neutrophils recovered (> 500 microliters) with 9 to 11 days and platelets recovered (> 5,000 microliters) within 8 to 13 days after the transplantation. No other serious complication was seen. Current topics regarding this procedure, problems to be solved, and prospects for further development are discussed.
在骨髓抑制性化疗后骨髓功能恢复期间，循环于外周血中的造血干细胞数量显著增加。在外周血干细胞移植中，这些干细胞被采集并冷冻保存，然后用于在骨髓破坏性（高剂量）抗癌治疗后恢复骨髓功能。与自体骨髓移植相比，该方法可使骨髓恢复得更快。最近，此方法已用于乳腺癌等对化疗敏感的实体瘤的高剂量化疗后。我们采用依托泊苷和顺铂进行高剂量化疗，随后进行外周血干细胞移植，治疗了5例胸内恶性肿瘤患者，包括小细胞肺癌。移植后9至11天中性粒细胞恢复（>500微升），8至13天血小板恢复（>5000微升）。未观察到其他严重并发症。本文讨论了关于该方法的当前热点、有待解决的问题以及进一步发展的前景。
