Hoka S
Department of Anesthesiology and critical Care Medicine, Faculty of Medicine, Kyvshu University, Fukuoka.
Masui. 1996 Jun;45(6):707-16.
Ventricular pressure-volume relationship enables us to understand the relationship among the heart, vasculature, and blood volume, since it provides, on a single plane, the preload, afterload, and cardiac contractility, which are major determinants of stroke volume. In addition, it is also possible to estimate cardio-vascular matching, namely the optimum of cardio-vascular interaction, by an analysis of ventricular pressure-volume relationship. Volatile anesthetics cause circulatory depression due primarily to decreases in cardiac contractility and stressed blood volume. The optimal treatment for it is to restore these decreases produced by volatile anesthetics. Thus, an increase in afterload by vasoactive agents may cause deterioration of cardio-vascular matching. A rationale for optimal perioperative circulatory management can be deduced from understanding a quantitative interaction among the heart, vasculature, and blood volume.
心室压力-容积关系使我们能够理解心脏、血管系统和血容量之间的关系，因为它在单一平面上提供了前负荷、后负荷和心脏收缩力，而这些是心输出量的主要决定因素。此外，通过分析心室压力-容积关系，还可以估计心血管匹配情况，即心血管相互作用的最佳状态。挥发性麻醉剂主要通过降低心脏收缩力和有效血容量导致循环抑制。其最佳治疗方法是恢复由挥发性麻醉剂引起的这些降低。因此，血管活性药物使后负荷增加可能会导致心血管匹配恶化。从理解心脏、血管系统和血容量之间的定量相互作用中可以推导出围手术期最佳循环管理的基本原理。
