[急性白血病患儿血浆中的转钴胺素II水平]
[Transcobalamin II levels in blood plasma of children with acute leukemia].
作者信息
Gudkova M V, Oreshkin A E, Miasishcheva N V, Lenskaia R V, Kurdiukov V B
出版信息
Gematol Transfuziol. 1996 Mar-Apr;41(2):10-3.
Transcobalamin II (TcII) level was studied in plasma of 40 children with acute leukemia. TcII is a cobalamin-binding protein which mediated the cellular uptake of Cbl and interacted with surface membrane receptor of hemopoietic cells. Plasma TcII and cobalofilins were analysed by PAGE using 57Co-cyanocobalamin. In addition, the mature human placenta with high specificity and affinity to TcII receptors was applied for TcII plasma identification. As compared to control, significant difference of TcII activity in the plasma of children with ALL was noted. There were children with low and high TcII concentration vs. control (484 +/- 42 and 1166 +/- 62, p > 0.001). Therefore, it is necessary to assay individually all the biochemical parameters of Cbl-transport system of children with ALL for adequate metabolic correction.
对40例急性白血病患儿的血浆进行了转钴胺素II（TcII）水平研究。TcII是一种钴胺素结合蛋白，介导钴胺素（Cbl）的细胞摄取，并与造血细胞的表面膜受体相互作用。采用57Co-氰钴胺通过聚丙烯酰胺凝胶电泳（PAGE）分析血浆TcII和钴胺素结合蛋白。此外，应用对TcII受体具有高特异性和亲和力的成熟人胎盘来鉴定血浆中的TcII。与对照组相比，注意到急性淋巴细胞白血病（ALL）患儿血浆中TcII活性存在显著差异。与对照组相比，有TcII浓度低和高的患儿（分别为484±42和1166±62，p>0.001）。因此，有必要对ALL患儿的Cbl转运系统的所有生化参数进行个体检测，以进行适当的代谢纠正。
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