Popova L M, Piradov M A
Anesteziol Reanimatol. 1996 Mar-Apr(2):13-5.
Presents the epidemiology, possible etiology, and pathogenesis of myasthenia, methods of diagnosis of the disease, and clinical picture of critical states. Describes the present-day methods of treating myasthenic and cholinergic crises: programmed plasmapheresis combined with hormone therapy, pulsed therapy with superhigh doses of corticosteroids, and the most novel method for the treatment of autoimmune diseases, intravenous infusions of immunoglobulins. Draws attention to indications for artificial ventilation of the lungs and tracheostomy. Enumerates the drugs which are not recommended for patients with myasthenia. Emphasizes that the use of the whole complex of modern therapeutic methods for the treatment of grave myasthenia helps reduce the mortality to virtually null.
介绍了重症肌无力的流行病学、可能的病因和发病机制、疾病的诊断方法以及危象的临床表现。描述了当前治疗重症肌无力危象和胆碱能危象的方法:序贯性血浆置换联合激素治疗、超大剂量皮质类固醇脉冲治疗以及治疗自身免疫性疾病的最新方法——静脉输注免疫球蛋白。提请注意肺人工通气和气管切开术的适应证。列举了不推荐给重症肌无力患者使用的药物。强调采用现代综合治疗方法治疗严重重症肌无力有助于将死亡率降至几乎为零。