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[基因组印记作为发育过程中基因功能的普遍机制]

[Genomic imprinting as a universal mechanism of gene function in development].

作者信息

Redina O E

出版信息

Genetika. 1996 May;32(5):609-13.

PMID:8755034
Abstract

The term genomic imprinting is used to designate the phenomenon of functional nonequivalence of alleles whose activities depend on their parental origin. A functional hemizygosity of the gene is characteristic for genomic imprinting. However, activities of alleles also depend on their parental origin in some cases of diallelic gene expression. These cases are described in the literature as possible examples of imprinting. In this paper, different manifestations of genomic imprinting are analyzed, and a hypothesis is suggested about the murine genome as a set of genes with different expressions of homologous alleles, whose activities depend on their parental origin.

摘要

基因组印记这一术语用于指代等位基因功能不等价的现象,其活性取决于亲本来源。基因的功能性半合子状态是基因组印记的特征。然而,在双等位基因表达的某些情况下,等位基因的活性也取决于其亲本来源。这些情况在文献中被描述为可能的印记示例。本文分析了基因组印记的不同表现形式,并提出了一个关于小鼠基因组的假说,即小鼠基因组是一组同源等位基因具有不同表达的基因集合,其活性取决于亲本来源。

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