Iakimovskiĭ A F
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 May-Jun;46(3):521-6.
The effects of three-week daily intrastriatal GABA (45 mcg) and bicucullin (5 mcg) microinjections on operant performance in the Skinner's box were studied in rats. GABA was shown to facilitate the operant responses (the rate of lever pressings increased, spontaneous motor activity became optimized). Bicucullin produced the opposite effects, i.e., the operant skill practically disappeared at the second-third week of injections. The operant behaviour was substantially influences by such factors as neurosurgery trauma, narcosis, and injections as demonstrated in control experiments. The findings suggest the involvement of GABAergic neostriatal system in realization of conditioned motor alimentary behaviour.
在大鼠中研究了为期三周每日纹状体内注射γ-氨基丁酸（45微克）和荷包牡丹碱（5微克）对斯金纳箱中操作性行为的影响。结果显示，γ-氨基丁酸能促进操作性反应（杠杆按压速率增加，自发运动活动得到优化）。荷包牡丹碱则产生相反的效果，即在注射的第二至三周，操作性技能几乎消失。对照实验表明，神经外科手术创伤、麻醉和注射等因素对操作性行为有显著影响。这些发现提示，γ-氨基丁酸能新纹状体系统参与了条件性运动摄食行为的实现。
