[幽门螺杆菌感染在胃腺癌和慢性胃炎中的患病率]
[Prevalence of Helicobacter pylori infection in gastric adenocarcinoma and chronic gastritis].
作者信息
Boixeda D, Gisbert J P, Arocena C, Cantón R, Alvarez Baleriola I, Martín de Argila C, García Plaza A
机构信息
Hospital Ramón y Cajal, Departamento de Medicina, Universidad de Alcalá de Henares, Madrid.
出版信息
Rev Esp Enferm Dig. 1996 Jun;88(6):403-8.
AIM
To describe the prevalence of Helicobacter pylori infection in patients with gastric adenocarcinoma, and compare it with that of patients with chronic gastritis.
METHODS
Fifty-four patients with endoscopically diagnosed gastric cancer (later confirmed histologically as gastric adenocarcinoma), and 60 patients with histologic chronic gastritis were studied. Age and sex distribution was similar in both groups. At endoscopy biopsy specimens were taken from antrum and body (H&E stain, Gram stain and culture).
RESULTS
H. pylori was found in 95% (95%CI = 86-98%) of patients with chronic gastritis, and in 41% (CI = 29-54%) of patients with gastric adenocarcinoma (p < 0.001). H. pylori was present in malignant tissue in 13% (CI = 6-24%) of cases, a significant lower (p < 0.01) percentage than in the gastric antrum and body.
CONCLUSION
The prevalence of H. pylori infection diagnosed by microbiologic and histologic methods in patients with gastric adenocarcinoma (41%) is significantly lower than in patients with chronic gastritis, its premalignant lesion. H. pylori was present less frequently in malignant tissue than in endoscopically normal mucosa.
目的
描述胃腺癌患者幽门螺杆菌感染的患病率，并与慢性胃炎患者的患病率进行比较。
方法
对54例经内镜诊断为胃癌（后经组织学确诊为胃腺癌）的患者和60例组织学诊断为慢性胃炎的患者进行研究。两组患者的年龄和性别分布相似。在内镜检查时，从胃窦和胃体取活检标本（苏木精-伊红染色、革兰氏染色和培养）。
结果
慢性胃炎患者中幽门螺杆菌的检出率为95%（95%置信区间=86%-98%），胃腺癌患者中为41%（置信区间=29%-54%）（p<0.001）。13%（置信区间=6%-24%）的病例在恶性组织中检测到幽门螺杆菌，这一比例显著低于胃窦和胃体（p<0.01）。
结论
通过微生物学和组织学方法诊断的胃腺癌患者中幽门螺杆菌感染的患病率（41%）显著低于其癌前病变慢性胃炎患者。幽门螺杆菌在恶性组织中的出现频率低于内镜检查正常的黏膜。
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