Cantorna M T, Hayes C E, DeLuca H F
Department of Biochemistry, University of Wisconsin, Madison 53706, USA.
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7861-4. doi: 10.1073/pnas.93.15.7861.
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.
实验性自身免疫性脑脊髓炎（EAE）是一种自身免疫性疾病，被认为是人类多发性硬化症（MS）的模型。用髓鞘碱性蛋白（MBP）免疫B10.PL小鼠可诱发EAE，而给予1,25 - 二羟基维生素D3 [1,25-(OH)2D3]可完全预防EAE。当在首次出现残疾症状时给予1,25-(OH)2D3，它也可以预防EAE的进展。停用1,25-(OH)2D3会导致EAE进展的恢复。因此，1,25-(OH)2D3的阻断作用是可逆的。维生素D缺乏会导致对EAE的易感性增加。因此，1,25-(OH)2D3或其类似物对MS的治疗可能具有重要意义。
