[Circadian rhythm of lutropin and follitropin in patients with chronic renal failure].

Dysfunction of the hypothalamic-pituitary-gonadal axis in patients with chronic renal failure is well documented. This study was aimed to answer the following questions: 1. Is there the circadian rhythm in serum concentration of lutropin and follitropin preserved in male patients with chronic renal failure. 2. Does hemodialysis, used in treatment of uremia, influence LH and FSH circadian variations. 3. Is there statistically significant difference between hormonal circadian rhythm determined on the day of hemodialysis and on the interdialytic day. Circadian patterns of LH and FSH and their characteristics were studied in 32 uremic men and 16 healthy men. 16 uremic males were non-dialyzed and 16 were hemodialyzed. In all investigated cases the basal serum concentrations of LH and FSH were measured 8-times a day at 3-hour intervals. LH and FSH serum concentrations were determined using an immunoradiometric assay. To estimate the circadian rhythms of the investigated hormones COSINOR computer analysis was used. The following results were obtained: 1. Significantly higher basal LH concentration in hemodialyzed patients, compared with the control group. 2. Absence of significant differences in LH serum concentration between hemodialyzed patients (on the day of dialysis and on the following day) and non-dialyzed patients. 3. Absence of LH circadian rhythm in both non-dialyzed and hemodialyzed uremic patients. 4. Existence of LH circadian rhythm in healthy subjects. 5. Significantly higher serum FSH concentration in hemodialyzed patients compared with healthy subjects.