Berent H, Wocial B, Kuczyńska K, Kochmański M, Ignatowska-Switalska H, Januszewicz A, Lapiński M, Lewandowski J, Januszewicz W
Kliniki Nadciśnienia Tetniczego i Chorób Naczyń Akademii Medycznej w Warszawie.
Pol Arch Med Wewn. 1996 Mar;95(3):190-7.
Investigated group consisted of 28 patients (21 female and 7 male) with pheochromocytoma in mean age of 39.9 +/- 13 years, while control group comprised 25 healthy volunteers in mean age 36.0 +/- 7.2 years. Following parameters were determined: plasma and blood viscosity, erythrocyte and platelets aggregation, erythrocyte deformability, hematocrit, beta-thromboglobulin plasma concentration, plasma fibrinogen concentration, lipids concentration, noradrenaline, adrenaline, serotonin, neuropeptide Y plasma concentrations. Plasma fibrinogen and beta-thromboglobulin were increased in pheochromocytoma before surgery after pharmacological treatment and also after excision of the tumor. Whereas altered erythrocyte deformability before any treatment, only. Plasma neuropeptide Y concentration was higher in pheochromocytoma before surgery and after pharmacological treatment. There was no correlation between plasma catecholamines, plasma fibrinogen, beta-thromboglobulin, and erythrocyte deformability. Our results suggest that rheological abnormalities observed in patients with pheochromocytoma may contribute to vascular complications in this subjects. Sympathetic nervous system seems to influence indirectly observed rheological abnormalities.
研究组由28例嗜铬细胞瘤患者组成（21例女性，7例男性），平均年龄为39.9±13岁，而对照组由25名健康志愿者组成，平均年龄为36.0±7.2岁。测定了以下参数：血浆和血液粘度、红细胞和血小板聚集、红细胞变形性、血细胞比容、血浆β-血小板球蛋白浓度、血浆纤维蛋白原浓度、脂质浓度、去甲肾上腺素、肾上腺素、血清素、血浆神经肽Y浓度。在手术前、药物治疗后以及肿瘤切除后，嗜铬细胞瘤患者的血浆纤维蛋白原和β-血小板球蛋白均升高。而仅在任何治疗前红细胞变形性发生改变。嗜铬细胞瘤患者手术前和药物治疗后的血浆神经肽Y浓度较高。血浆儿茶酚胺、血浆纤维蛋白原、β-血小板球蛋白和红细胞变形性之间无相关性。我们的结果表明，嗜铬细胞瘤患者中观察到的血液流变学异常可能导致该类患者出现血管并发症。交感神经系统似乎间接影响观察到的血液流变学异常。
