Kubeyinje E P, C'Mathur M
Arar Central Hospital, Northern Frontier, Saudi Arabia.
East Afr Med J. 1996 May;73(5):313-5.
One hundred and thirty seven adults with adverse cutaneous reactions to systemic drugs seen in two referral centres in northern Saudi Arabia, over a period of three years were reviewed. Urticaria, sometimes occurring with angioedema was the most common pattern observed. It was seen in 35% of cases and the culprit drugs in most instances were the salicylates and the penicillins. The combination of trimethoprim and sulfamethoxazole was the culprit drug in 70% of cases of fixed drug eruptions and 75% of cases of erythema multiforme. Although there were no recorded fatalities, there was prolonged morbidity in patients with the Stevens-Johnson's syndrome, and unsightly residual hyperpigmentations in those with fixed drug eruptions. The occurrence of these adverse reactions were frequently associated with inappropriate polypharmacy and this practice should be discouraged.
对沙特阿拉伯北部两个转诊中心在三年时间里接诊的137例有全身性药物皮肤不良反应的成年人进行了回顾性研究。荨麻疹，有时伴有血管性水肿，是观察到的最常见症状。35%的病例出现该症状，大多数情况下，罪魁祸首药物是水杨酸盐类和青霉素类。在70%的固定性药疹病例和75%的多形红斑病例中，复方新诺明是罪魁祸首药物。虽然没有记录到死亡病例，但史蒂文斯-约翰逊综合征患者存在长期发病情况，固定性药疹患者有难看的残留色素沉着。这些不良反应的发生常常与不合理的联合用药有关，这种做法应予以摒弃。
