• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Natural leukocyte interferon-alpha therapy in patients with chronic granulocytic leukemia who have antibody-mediated resistance to treatment with recombinant interferon-alpha.

作者信息

Tefferi A, Grendahl D C

机构信息

Division of Hematology and Internal Medicine, Pharmacy, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Am J Hematol. 1996 Jul;52(3):231-3. doi: 10.1002/(SICI)1096-8652(199607)52:3<231::AID-AJH20>3.0.CO;2-H.

DOI:10.1002/(SICI)1096-8652(199607)52:3<231::AID-AJH20>3.0.CO;2-H
PMID:8756097
Abstract

Two patients with chronic-phase chronic granulocytic leukemia initially responded to recombinant interferon alpha-2a (rIFN-alpha-2a) but relapsed as a result of development of hightiter neutralizing antibodies to rIFN-alpha-2a. Both patients were subsequently treated with natural leukocyte IFN-alpha (IFN-alpha-n3), and one of the two patients achieved a durable second hematologic and cytogenetic remission. IFN-alpha-n3 may be considered for patients in whom antibody-mediated resistance to rIFN-alpha-2a develops.

摘要

相似文献

1
Natural leukocyte interferon-alpha therapy in patients with chronic granulocytic leukemia who have antibody-mediated resistance to treatment with recombinant interferon-alpha.
Am J Hematol. 1996 Jul;52(3):231-3. doi: 10.1002/(SICI)1096-8652(199607)52:3<231::AID-AJH20>3.0.CO;2-H.
2
Interferon-alpha neutralizing antibodies in HIV and chronic HCV patients treated with natural-source human leukocyte-derived interferon-alpha n3.接受天然来源人白细胞衍生干扰素-α n3治疗的HIV和慢性丙型肝炎患者体内的α干扰素中和抗体
Hum Antibodies. 1997;8(3):129-36.
3
[Treatment with lymphoblastoid alpha interferon in patients with chronic myeloid leukemia refractory to recombinant interferon alpha 2].用淋巴母细胞α干扰素治疗对重组α2干扰素难治的慢性髓性白血病患者
Sangre (Barc). 1998 Oct;43(5):443-6.
4
Alpha-interferon with very-low-dose donor lymphocyte infusion for hematologic or cytogenetic relapse of chronic myeloid leukemia induces rapid and durable complete remissions and is associated with acceptable graft-versus-host disease.α干扰素联合极低剂量供体淋巴细胞输注治疗慢性髓性白血病血液学或细胞遗传学复发可诱导快速且持久的完全缓解，并与可接受的移植物抗宿主病相关。
Biol Blood Marrow Transplant. 2004 Mar;10(3):204-12. doi: 10.1016/j.bbmt.2003.11.003.
5
Response to sequential treatment with lymphoblastoid interferon-alpha in patients with Ph+ chronic myeloid leukemia unresponsive to recombinant interferon-alpha (rIFN alpha 2a) and neutralizing-rIFN alpha 2a antibodies negative.对重组干扰素-α（rIFNα2a）无反应且中和性rIFNα2a抗体阴性的Ph+慢性髓性白血病患者接受淋巴母细胞样干扰素-α序贯治疗的反应
Haematologica. 1997 May-Jun;82(3):348-50.
6
Epitopes recognized by neutralizing therapy-induced human anti-interferon-alpha antibodies are localized within the N-terminal functional domain of recombinant interferon-alpha 2.
Eur J Immunol. 1996 Sep;26(9):2155-9. doi: 10.1002/eji.1830260929.
7
[Clinical significance of neutralizing anti-interferon antibodies in chronic hepatitis B patients treated with recombinant interferon-alpha].[重组α干扰素治疗慢性乙型肝炎患者中中和性抗干扰素抗体的临床意义]
Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):205-7.
8
Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies.毛细胞白血病中与中和性抗干扰素抗体相关的重组干扰素α-2a耐药性。
N Engl J Med. 1988 Jun 2;318(22):1409-13. doi: 10.1056/NEJM198806023182201.
9
Resistance to recombinant alpha interferon therapy in idiopathic mixed cryoglobulinemia: reinduction of remission by natural alpha interferon both in antibody-positive and -negative patients.
J Biol Regul Homeost Agents. 1994 Apr-Jun;8(2):56-9.
10
Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha.慢性粒细胞白血病患者经α干扰素治疗达到细胞遗传学和血液学缓解后，其T细胞Th1细胞因子合成的恢复情况。
Clin Cancer Res. 2000 May;6(5):1671-7.