Sygitowicz G, Minor A, Pachecka J, Jura E, Ryglewicz D, Członkowska A
Katedry i Zakładu Biochemii i Chemii Klinicznej AM w Warszawie.
Neurol Neurochir Pol. 1996 Mar-Apr;30(2):213-9; quiz 220.
The concentrations were determined of triglycerides (TG), total cholesterol (Ch), high density fraction of (HDL-Ch), low density fraction of cholesterol (LDL-Ch), apolipoprotein B (apo-B) in patients with dementia of Alzheimer type (DAT, 14 patients) and multi-infarct dementia (MID, 63 patients). No significant differences in the estimated lipid parameters in both groups were found, except the calculated value of atherogenic index (Ch/HDL-Ch), which was significantly higher in patients with MID. Our results suggest that this parameter is a much more sensitive atherogenic indicator in blood-vessels than other tested lipid parameters. This finding may influence the therapeutic approach to patients with dementia.
测定了14例阿尔茨海默型痴呆（DAT）患者和63例多发梗死性痴呆（MID）患者的甘油三酯（TG）、总胆固醇（Ch）、高密度脂蛋白胆固醇（HDL-Ch）、低密度脂蛋白胆固醇（LDL-Ch）及载脂蛋白B（apo-B）的浓度。除致动脉粥样硬化指数（Ch/HDL-Ch）的计算值外，两组的估计血脂参数无显著差异，该指数在MID患者中显著更高。我们的结果表明，该参数在血管中是比其他检测的血脂参数更敏感的动脉粥样硬化指标。这一发现可能会影响痴呆患者的治疗方法。
