Meek A G, Park T L, Weiss T A, Bethune W A
Department of Radiation Oncology, University Hospital, Stony Brook, NY 11794-7028, USA.
Radiology. 1996 Sep;200(3):615-9. doi: 10.1148/radiology.200.3.8756905.
To assess local control when radiation therapy is delayed to complete chemotherapy in breast conservation therapy.
Breast conservation therapy was performed in 310 cases in 297 patients (aged 24-85 years) with stage 0-II breast cancer. Adjuvant chemotherapy was used in 76 cases. The authors analyzed the time between diagnosis and radiation therapy and correlated these findings with local control of disease.
The time between diagnosis and radiation therapy in the 247 cases treated without chemotherapy-related delay was 2-59 weeks (mean, 8 weeks). The interval in the 63 cases with chemotherapy-related delay was 12-63 weeks (mean, 31 weeks; P < .001). Ten of the 11 cases with an in breast relapse were in the group treated without a delay (P = .57).
Delaying radiation therapy for chemotherapy does not compromise local control.
评估在保乳治疗中延迟放疗以完成化疗时的局部控制情况。
对297例年龄在24 - 85岁、患有0 - II期乳腺癌的患者中的310例进行了保乳治疗。76例患者使用了辅助化疗。作者分析了诊断与放疗之间的时间，并将这些结果与疾病的局部控制情况相关联。
247例无化疗相关延迟的患者，诊断与放疗之间的时间为2 - 59周（平均8周）。63例有化疗相关延迟的患者，该间隔为12 - 63周（平均31周；P <.001）。11例乳腺内复发的患者中有10例在未延迟治疗的组中（P =.57）。
为进行化疗而延迟放疗不会影响局部控制。
