Jewell F M, Davies A, Sandhu B, Duncan A, Grier D
Department of Clinical Radiology, Bristol Children's Hospital, UK.
Br J Radiol. 1996 Jun;69(822):508-14. doi: 10.1259/0007-1285-69-822-508.
This study was a retrospective evaluation of the use of technetium-99m hexamethylpropyleneamineoxime (HMPAO) labelled leucocytes in the investigation of suspected inflammatory bowel disease in children. The images were analysed in 35 children and the findings were compared with the results of endoscopy/biopsy, barium studies and antinuclear cytoplasm antibody (ANCA) serology. The sensitivity of the white cell scan was 83% and the specificity 81%. This compares well with other studies in adults and is superior to barium investigations. The technique is recommended as a first line investigation to detect inflammatory bowel disease with a resultant reduction in the use of endoscopy and barium imaging.
本研究是一项回顾性评估，旨在探讨锝-99m六甲基丙烯胺肟（HMPAO）标记白细胞在儿童疑似炎症性肠病检查中的应用。对35名儿童的图像进行了分析，并将结果与内镜检查/活检、钡剂造影和抗核细胞质抗体（ANCA）血清学结果进行了比较。白细胞扫描的敏感性为83%，特异性为81%。这与其他针对成人的研究结果相当，且优于钡剂检查。建议将该技术作为检测炎症性肠病的一线检查方法，从而减少内镜检查和钡剂成像的使用。
