Davison S M, Chapman S, Murphy M S
Department of Gastroenterology, Birmingham Children's Hospital and Institute of Child Health, University of Birmingham, Clinical Research Block, Whittall Street, Birmingham B4 6NH, UK.
Arch Dis Child. 2001 Jul;85(1):43-6. doi: 10.1136/adc.85.1.43.
To investigate the use of (99m)Tc-HMPAO (hexamethyl propylene amine oxime) leucocyte scintigraphy as a non-invasive screening test for inflammatory bowel disease.
10 children with suspected Crohn's disease, in whom routine investigation using barium contrast radiology, upper gastrointestinal endoscopy, colonoscopy, and mucosal biopsies had identified severe gastroduodenal and/or jejunal involvement.
(99m)Tc-HMPAO leucocyte scintigraphic studies performed in each of these cases were assessed by a radiologist who was blinded to the disease distribution.
In nine cases there was no scintigraphic evidence of inflammation in the proximal gastrointestinal tract. The 10th child had both gastroduodenal and jejunal involvement, but scintigraphy only revealed faint jejunal positivity.
(99m)Tc-HMPAO leucocyte scintigraphy should not be depended upon as a screening test for Crohn's disease. False negative results are likely in cases with Crohn's disease confined to the proximal gastrointestinal tract.
探讨用锝（99m）-六甲基丙烯胺肟（HMPAO）白细胞闪烁扫描术作为炎性肠病的一种非侵入性筛查试验。
10名疑似克罗恩病的儿童，通过钡剂造影放射学、上消化道内镜检查、结肠镜检查及黏膜活检等常规检查已确定其存在严重的胃十二指肠和/或空肠受累。
对这些病例中的每一例进行的锝（99m）-HMPAO白细胞闪烁扫描研究由一位对疾病分布不知情的放射科医生进行评估。
9例患者的上消化道近端无闪烁扫描炎症证据。第10名儿童胃十二指肠和空肠均受累，但闪烁扫描仅显示空肠轻度阳性。
锝（99m）-HMPAO白细胞闪烁扫描术不应作为克罗恩病的筛查试验。局限于上消化道的克罗恩病病例可能会出现假阴性结果。
