Behr C, Poupot R, Peyrat M A, Poquet Y, Constant P, Dubois P, Bonneville M, Fournie J J
Unité d'Immunologie Moléculaire des Parasites, URA CNRS 1960, Institu Pasteur, Paris, France.
Infect Immun. 1996 Aug;64(8):2892-6. doi: 10.1128/iai.64.8.2892-2896.1996.
The presence in Plasmodium falciparum of a mitogenic factor for the major human blood gammadelta T-cell subset has been known for years. These gammadelta T cells bearing T-cell receptor Vgamma9 and Vdelta2 variable regions also respond to Mycobacterium tuberculosis, through recognition of several phosphorylated nonpeptidic antigens. In this study, we undertook a better characterization of the malarial stimulus and show that the polygonal activation of Vgamma9/Vdelta2 gammadelta T cells by P. falciparum schizonts is also and exclusively attributable to two phosphorylated malarial compounds. The finding of such stimuli in eukaryotic cells evidence an antigenic link between intracellular parasites as different as Plasmodium and Mycobacterium species. Hence, phosphorylated antigens could be involved in a common pattern of transdisease T-cell responses against various human pathogens.
多年来，人们已经知道恶性疟原虫中存在一种针对主要人类血液γδ T细胞亚群的促有丝分裂因子。这些携带T细胞受体Vγ9和Vδ2可变区的γδ T细胞，通过识别几种磷酸化的非肽抗原，也对结核分枝杆菌产生反应。在本研究中，我们对疟疾刺激进行了更好的表征，并表明恶性疟原虫裂殖体对Vγ9/Vδ2 γδ T细胞的多克隆激活也完全归因于两种磷酸化的疟疾化合物。在真核细胞中发现此类刺激物，证明了疟原虫和分枝杆菌等不同细胞内寄生虫之间的抗原联系。因此，磷酸化抗原可能参与了针对各种人类病原体的跨疾病T细胞反应的共同模式。
