Migliaccio A R, Vannucchi A M, Migliaccio G
Laboratory of Hematopoietic Growth Factors, New York Blood Center, NY 10021, USA.
Int J Hematol. 1996 Jul;64(1):1-29. doi: 10.1016/0925-5710(96)00465-3.
The number of circulating red cells is regulated by the daily balance between two processes: the destruction of the old red cells in the liver and the generation of new cells in the bone marrow. The process during which hematopoietic stem cells generate new red cells is called erythropoiesis. This article describes the most recent advances in molecular and cellular biology which have allowed the identification of the molecular mechanisms involved in the process of erythroid differentiation. It reviews the cellular compartments involved in the process, what is known on how these cells respond to erythroid specific growth factors and how the cells progressively activate specific transcription factors in order to express genes involved in the establishment of the erythroid phenotype.
肝脏中衰老红细胞的破坏以及骨髓中新细胞的生成。造血干细胞生成新红细胞的过程称为红细胞生成。本文描述了分子和细胞生物学的最新进展，这些进展使得参与红系分化过程的分子机制得以确定。它回顾了该过程中涉及的细胞区室，已知这些细胞如何对红系特异性生长因子作出反应，以及细胞如何逐步激活特定转录因子以表达参与建立红系表型的基因。
