化脓性肝脓肿与急性曼氏血吸虫病：3例报告及实验研究
Pyogenic liver abscesses and acute schistosomiasis mansoni: report on 3 cases and experimental study.
作者信息
Teixeira R, Ferreira M D, Coelho P M, Filho G B, Azevedo Júnior G M, Lambertucci J R
机构信息
Department of Internal Medicine, Federal University of Minas Gerais, Brazil.
出版信息
Trans R Soc Trop Med Hyg. 1996 May-Jun;90(3):280-3. doi: 10.1016/s0035-9203(96)90249-7.
Three children with acute schistosomiasis mansoni developed pyogenic liver abscesses. The abscesses were diagnosed by ultrasonography and confirmed during laparotomy. Staphylococcus aureus were the sole bacteria isolated from the abscesses. An experimental study was carried out in mice to establish whether schistosomiasis is a predisposing cause for pyogenic liver abscesses. Seventeen mice (group 1) were infected with 40 Schistosoma mansoni cercariae (LE strain) and 60 d later inoculated intravenously with a strain of Staph. aureus, isolated from a patient with bacteraemia; 17 mice infected with Sch. mansoni (group 2), 19 infected with bacteria alone (group 3), and 18 uninfected mice (group 4), served as controls. Thirteen group 1 mice (77%) developed multiple liver abscesses while none was observed in the controls. These results indicate that acute schistosomiasis mansoni concurrent with Staph. aureus bacteraemia favours the colonization of the liver by bacteria and the development of pyogenic hepatic abscesses.
三名急性曼氏血吸虫病患儿发生了化脓性肝脓肿。脓肿通过超声检查诊断，并在剖腹手术中得到证实。从脓肿中分离出的唯一细菌是金黄色葡萄球菌。在小鼠身上进行了一项实验研究，以确定血吸虫病是否是化脓性肝脓肿的诱发因素。17只小鼠（第1组）感染40条曼氏血吸虫尾蚴（LE株），60天后静脉注射从一名菌血症患者分离出的一株金黄色葡萄球菌；17只感染曼氏血吸虫的小鼠（第2组），19只仅感染细菌的小鼠（第3组），以及18只未感染的小鼠（第4组）作为对照。第1组的13只小鼠（77%）出现了多发性肝脓肿，而对照组未观察到。这些结果表明，急性曼氏血吸虫病并发金黄色葡萄球菌菌血症有利于细菌在肝脏定植并发展为化脓性肝脓肿。
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