Tverskoy M, Fleyshman G, Bachrak L, Ben-Shlomo I
Department of Anesthesia and Intensive Care, Rebecca Sieff' Government Hospital, Safed, Israel.
Anaesthesia. 1996 Jul;51(7):652-3. doi: 10.1111/j.1365-2044.1996.tb07847.x.
The hypnotic dose-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic or lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
将丙泊酚的催眠剂量反应与其与布比卡因诱导的脊髓阻滞或肌肉注射12.5 mg布比卡因联合使用的情况进行比较，105名男性被分为三组，每组35人，接受下腹部、盆腔或下肢手术。使用自抽样分析确定每组的剂量反应曲线。结果发现，T8-T9水平的布比卡因诱导的脊髓阻滞可使丙泊酚的半数有效剂量降低39%。虽然脊髓阻滞对催眠作用的这种增强主要归因于传入输入的减少，但药物之间效力的差异表明还有其他因素在起作用。
