Etherington D J, Pheby D F, Bray F I
Department of Social Medicine, University of Bristol, U.K.
Eur J Cancer. 1996 Jun;32A(7):1189-97. doi: 10.1016/0959-8049(96)00060-3.
To investigate the relationship of domestic radon levels and cancer, the incidence of 14 major cancers in Devon and Cornwall were examined in relation to the local radon levels. Cancer registrations for 1989-1992 were provided by the South-Western Regional Cancer Registry. The average radon levels for postcode sectors were sorted into ten categories from low (< 40 Bq/m3) to extremely high (> or = 230 Bq/m3) and age-standardised incidence rates were calculated for each radon category. The incidence rates for lung cancer, where radon has been claimed to be a risk factor, were very similar across all domestic radon categories. Only non-melanoma skin cancers, showed a significant increase in incidence in the high-radon postcode sectors (> or = 100 Bq/m3) compared with the low-radon sectors (< 60 Bq/m3) and this effect was observed for both sexes. The remaining 12 cancer sites showed no significant trend in incidence rates with increasing radon concentration. There was no significant difference in corrected survival rates for any cancer site between the low- and high-radon areas. The possible contribution of confounding factors to the results of this study is discussed.
为了研究国内氡水平与癌症之间的关系，对德文郡和康沃尔郡14种主要癌症的发病率与当地氡水平进行了调查。1989 - 1992年的癌症登记数据由西南地区癌症登记处提供。邮政编码区域的平均氡水平被分为从低（<40贝克勒尔/立方米）到极高（≥230贝克勒尔/立方米）的十个类别，并为每个氡类别计算年龄标准化发病率。在所有家庭氡类别中，肺癌的发病率非常相似，而氡被认为是肺癌的一个风险因素。只有非黑色素瘤皮肤癌，与低氡区域（<60贝克勒尔/立方米）相比，在高氡邮政编码区域（≥100贝克勒尔/立方米）的发病率显著增加，并且这种影响在两性中均有观察到。其余12个癌症部位的发病率没有随着氡浓度的增加而呈现出显著趋势。在低氡和高氡区域之间，任何癌症部位的校正生存率没有显著差异。本文讨论了混杂因素对本研究结果可能产生的影响。
