[Glutamine dipeptide enriched nutritional solutions attenuate bacterial translocation in rats after 60% intestinal resections].

OBJECTIVE

To investigate the effects of alanyl-glutamine dipeptide (Ala-Gln) enriched parenteral nutrition solution on intestinal mucosa or gut barrier since traditional parenteral nutrition leads to bacterial translocation.

METHODS

The moderate operation stress was induced by 60% resection of small intestine. Qualified rats distributed in three groups: Chow group (n = 10) received standard rat chow, PN group (n = 10) received traditional parenteral nutrition solution only, and Ala-Gln group (n = 10) received glutamine dipeptide enriched nutritional solutions (3% Ala-Gln). Rats were maintained on their respective diets for 7 days.

RESULTS

Chow group and Ala-Gln group maintained serum glutamine concentration, villus height and mucosal thickness. The bacterial translocation rate in Chow group and Ala-Gln group was 20% and in PN group 70%.

CONCLUSION

Results demonstrate that Ala-Gln enriched nutritional solutions maintain intestinal adaptation and gut barrier function after massive intestinal resection.