Liu F, Liu D, Rao M
Beijing General Hospital.
Zhonghua Yi Xue Za Zhi. 1996 Feb;76(2):132-4.
To evaluate the effect of nimodipine and papaverine (Pap) on the spastic arteries with delayed cerebral vasospasm (DCVS) in dogs.
A model of DCVS in dogs was induced by the cisterna magna injections of fresh autologous blood twice. The diameter of the basilar arteries with and without DCVS was measured with the aid of a JVC operative microes cope in vivo after nimodipine and Pap were directly placed around the arteries.
The dilation of the basilar arteries was obviously induced by application of nimodipine and Pap in the dogs without DCVS no dilation was induced by application of nimodipine and slight dilation by application of Pap but in those with DCVS.
The cerebral blood flow is improved by the effect of nimodipine on non-spastic arteries. Pap has been found to reverse slightly the narrowing of the basilar arteries with DCVS and to dilate the arteries without DCVS, but the vasodilation effect is transient.
评估尼莫地平和罂粟碱（Pap）对犬迟发性脑血管痉挛（DCVS）所致痉挛动脉的作用。
通过两次枕大池注射新鲜自体血诱导犬DCVS模型。在尼莫地平和Pap直接置于动脉周围后，借助JVC手术显微镜在体内测量有和无DCVS的基底动脉直径。
在无DCVS的犬中，应用尼莫地平和Pap可明显诱导基底动脉扩张；在有DCVS的犬中，应用尼莫地平未诱导出扩张，应用Pap仅诱导出轻微扩张。
尼莫地平对非痉挛动脉的作用可改善脑血流。已发现Pap可使有DCVS的基底动脉狭窄略有逆转，并使无DCVS的动脉扩张，但血管扩张作用是短暂的。
