[Gonadotropins stimulate the proliferation of human epithelial ovarian cancer cell].

OBJECTIVE

To observe the effect of FSH and LH on the proliferation of human epithelial ovarian cancer cell.

METHOD

Human epithelial ovarian cancer AO cells were incubated with follicle stimulating hormone (FSH) and luteinizing hormone (LH) (2U/L and 2.5U/L respectively). They were detected for proliferation by the use of the immunohistochemical technique and morphology.

RESULTS

The positive rate of proliferating cell nuclear antigen expressed in the cancer cell was increased significantly (p < 0.05) indicating its proliferation stimulating effect by FSH. The mitosis of cancer cells was increased by FSH and by LH (35%, 16% respectively).

CONCLUSIONS

It is suggested that FSH and LH can stimulate the proliferation of epithelial ovarian cancer cell, and they may play an important in the development of epithelial ovarian cancer.