[卵巢癌中胎盘碱性磷酸酶的检测]
[Detection of placental alkaline phosphatase in ovarian cancer].
作者信息
Wang R, Song L, Ding L
机构信息
Binzhou Medical College.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1996 Feb;31(2):107-9.
OBJECTIVE
To establish a method for diagnosis of malignant tumors by determination of the placental alkaline phosphatase (PLAP) in serum.
METHODS
A solid phase enzyme immunoassay was adopated by an antibody against PLAP. PLAP in serum of 81 patients with malignant tumor and 86 healthy people as control were determined.
RESULTS
In the control group, the PLAP activity showed deviative distribution, the 95th percentile values of PLAP in control group was 3.8U/L. If this value served as normal cut-off line, 18 cases among 81 patients with malignant tumors were positive. The positive rate was 22.2%, but the positive rates in ovarian cancer was 61.9%.
CONCLUSIONS
The increasing of serum PLAP may be helpful for the diagnosis of malignant tumors especially ovarian cancer.
目的
通过检测血清中胎盘碱性磷酸酶（PLAP）建立一种诊断恶性肿瘤的方法。
方法
采用抗PLAP抗体的固相酶免疫测定法。测定81例恶性肿瘤患者血清中的PLAP，并以86例健康人作为对照。
结果
对照组中，PLAP活性呈偏态分布，对照组PLAP的第95百分位数为3.8U/L。以此值作为正常临界值，81例恶性肿瘤患者中有18例呈阳性。阳性率为22.2%，但卵巢癌的阳性率为61.9%。
结论
血清PLAP升高可能有助于恶性肿瘤尤其是卵巢癌的诊断。
Zotero 插件