Plavsić V
Endokrinoloski laboratorij, KBC Rebro, Zagreb.
Lijec Vjesn. 1996 Mar;118 Suppl 1:9-10.
Cholesterol and steroid hormone biosynthesis, enzymes which catalyze each step in the biosynthesis, their localization and the genes that encode them are presented. The simplified mechanism of the enzyme cytochrome P450 action is described. It comprises alternative oxidation and reduction of flavoprotein adrenodoxin reductase, adrenodoxin and cytochrome P450. delta 4 and delta 5 pathways for androgen biosynthesis and an alternative biosynthetic pathway for aldosterone and cortisol biosynthesis are also described.
介绍了胆固醇和类固醇激素的生物合成、催化生物合成各步骤的酶、它们的定位以及编码它们的基因。描述了细胞色素P450酶作用的简化机制。它包括黄素蛋白肾上腺皮质铁氧还蛋白还原酶、肾上腺皮质铁氧还蛋白和细胞色素P450的交替氧化和还原。还描述了雄激素生物合成的δ4和δ5途径以及醛固酮和皮质醇生物合成的另一种生物合成途径。
