Alam I, Ferrell L D, Bass N M
Department of Medicine, University of California, San Francisco, USA.
Am J Gastroenterol. 1996 Aug;91(8):1626-30.
Nonsteroidal anti-inflammatory drugs are widely used, but the potential hepatotoxic side effects are not always appreciated. Herein, we report the first case, to our knowledge, of an atopic patient in whom severe cholestatic jaundice from bile ductopenia developed 3 wk after initiation of ibuprofen therapy. This drug-induced vanishing bile duct syndrome is probably an immunological (hypersensitivity) reaction. Vanishing bile duct syndrome as a consequence of ibuprofen use should be considered as a potential cause of chronic cholestasis when other more common etiologies have been excluded.
非甾体抗炎药被广泛使用，但其潜在的肝毒性副作用并非总能得到重视。据我们所知，本文报告了首例布洛芬治疗3周后出现严重胆汁淤积性黄疸的特应性患者，其病因是胆管减少。这种药物性胆管消失综合征可能是一种免疫（超敏）反应。当排除其他更常见的病因后，因使用布洛芬导致的胆管消失综合征应被视为慢性胆汁淤积的潜在病因。
