一种与组蛋白基因启动子的新型顺式作用元件结合的锌指型转录因子WZF-1可抑制其自身的启动子。
A zinc-finger-type transcription factor WZF-1 that binds to a novel cis-acting element of histone gene promoters represses its own promoter.
作者信息
Sakamoto A, Omirulleh S, Nakayama T, Iwabuchi M
机构信息
Department of Botany, Faculty of Science, Kyoto University, Japan.
出版信息
Plant Cell Physiol. 1996 Jun;37(4):557-62. doi: 10.1093/oxfordjournals.pcp.a028980.
Abstract
WZF-1 is a zinc-finger protein which binds to the wheat histone gene promoter. Southwestern-binding analyses revealed that it bound a CACTC sequence, a novel positive cis-acting element. The activity of WZF-1 gene promoter, containing six CACTC sequences, was markedly reduced when WZF-1 was co-expressed, suggesting that WZF-1 is a transcriptional repressor.
摘要
WZF-1是一种与小麦组蛋白基因启动子结合的锌指蛋白。Southwestern杂交分析表明，它与一个CACTC序列结合，这是一个新的正向顺式作用元件。当WZF-1共表达时，含有六个CACTC序列的WZF-1基因启动子的活性显著降低，这表明WZF-1是一种转录抑制因子。
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