Jault F, Gandjbakhch I, Rama A, Nataf P, Dorent R, Bors V, Pavie A, Cabrol C
Service de chirurgie thoracique et cardiovasculaire, höpital de la Pitié, Paris.
Arch Mal Coeur Vaiss. 1996 Jun;89(6):679-84.
Between January 1973 and December 1993, 66 patients underwent surgery in our department for hypertrophic obstructive cardiomyopathy; mean basal outflow gradient was 48.4 +/- 36 mmHg, 20 patients had mitral valve lesions. Thirty six patients underwent myotomy-myomectomy alone, 13 mitral valve replacement alone, and 17 both myotomy-myomectomy and mitral valve replacement. The 30-day mortality rate was 7.5% for all patients; predominant risk factors were gender (female), greater cardiothoracic ratio, preoperative episodes of atrial fibrillation and lack of syncope. Overall survival rate (operative mortality included) was 65.3 +/- 8.6% at 13 years. Predominant risk factors for late mortality were the same than above, plus mitral valve replacement; so mitral valve repair, whenever feasible should be undertaken. Forty nine patients are still followed up: 46 are asymptomatic; Doppler mean basal outflow gradient was reduced to 10 +/- 1.4 mmHg. In conclusion, surgery relieves symptoms and outflow obstruction, and allows mitral valve reconstruction.
1973年1月至1993年12月期间,我科对66例肥厚性梗阻性心肌病患者进行了手术;平均基础流出道压差为48.4±36 mmHg,20例患者合并二尖瓣病变。36例患者仅接受了心肌切开-心肌切除术,13例仅接受了二尖瓣置换术,17例同时接受了心肌切开-心肌切除术和二尖瓣置换术。所有患者的30天死亡率为7.5%;主要危险因素为性别(女性)、心胸比率较大、术前房颤发作和无晕厥。包括手术死亡率在内的13年总生存率为65.3±8.6%。晚期死亡的主要危险因素与上述相同,此外还有二尖瓣置换术;因此,只要可行,应进行二尖瓣修复。49例患者仍在随访中:46例无症状;多普勒平均基础流出道压差降至10±1.4 mmHg。总之,手术可缓解症状和流出道梗阻,并允许进行二尖瓣重建。